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Also, fatty acid catabolism (beta-oxidation) occurs in the mitochondria, but when it is reduced, it causes an accumulation of diacylglycerol and lipids, leading to an overproduction of ROS and the activation of kinase C

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10.1073/pnas.1302560110 Proc

M., Nam, S., Smith, L

Studies involving approximately 900 participants demonstrated that AOD-9604 produces fat metabolism effects with excellent safety and tolerability profiles